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The dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase plasma concentrations of IBRANCE and should be avoided. Across clinical trials (PALOMA-1, PALOMA-2, PALOMA-3), 1. Grade 3 or 4, generic mobic prices and websites no fatal cases were reported. One death due to neutropenic sepsis was observed in PALOMA-3.

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